By Günter Breithardt,Martin Borggrefe,John A. Camm,Mohammad Shenasa

The prior 10 years have obvious a amazing swap within the method of cardiac arrhythmias, from a place of self belief and a sense of overall healthiness approximately pharmacological therapy to a scenario during which there's now marked uncertainty and normal apprehension concerning the function of antiarrhythmic medicines. till really lately the present inspiration in antiarrhythmic treatment was once that arrhythmias should be managed through medicines which slowed conduction or suppressed automaticity, ambitions good served via the sodium channel-blocking medicinal drugs and glycosides. Drug re­ seek used to be dependent principally at the improvement of brokers mimicking these already to be had, yet with higher efficacy, fewer unintended effects or a extra beneficial phar­ macokinetic profile. the solid trial stands proud as a landmark within the evolution of arrhytmia deal with­ ment; infrequently has a unmarried trial had the sort of profound impression not just on medical prac­ tice, but in addition usually process of these eager about the examine, improvement and law of antiarrhythmic medicines. the result of the solid trial, designed to redress the shortcomings of past trials which had didn't show the predicted development in mortality post-myocardial infarction with using classification I brokers, are popular. the solid and solid II confirmed a rise in mor­ tality linked to the lively agent (encainide, flecainide or morizicine) com­ pared to placebo therapy. They firmly demonstrated the aptitude risk within the use of sophistication I drugs.

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Antiarrhythmic Drugs: Mechanisms of Antiarrhythmic and Proarrhythmic Actions by Günter Breithardt,Martin Borggrefe,John A. Camm,Mohammad Shenasa


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