New PDF release: Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles

By Kevin H. Shaughnessy,Engelbert Ciganek,Rebecca B. DeVasher,Scott E. Denmark

The metal-catalyzed amination of aryl and alkenyl electrophiles has constructed right into a familiar method for the synthesis of usual items, lively pharmaceutical materials, agricultural chemical compounds, and fabrics for molecular electronics. Copper catalysts advertise the coupling of a variety of nitrogen nucleophiles, together with amines, amides, and heteroaromatic nitrogen compounds with aryl and alkenyl halides. The reactivity profile of copper catalysts is complementary to that of palladium catalysts in lots of circumstances. Copper catalysts are powerful with much less nucleophilic nitrogen nucleophiles, resembling amides and azoles, while palladium catalysts are greater with extra nucleophilic amine nucleophiles. Copper is an enticing replacement to palladium as a result of its considerably cheaper price. additionally, excessive job palladium catalysts require dear and sometimes air-sensitive ligands, while the fashionable copper platforms use fairly good and cheap diamine or amino acid ligands. Copper-catalyzed C?N coupling reactions are tolerant of quite a lot of sensible teams and feature been utilized to the synthesis of numerous complicated typical items. major paintings has additionally been performed to appreciate the mechanism of those reactions. present mechanistic realizing of those methodologies is roofed during this monograph.

The contents of the booklet are taken from the excellent evaluation of the subject within the natural Reactions sequence. optimum experimental stipulations for the amination of aryl and alkenyl halides with all sessions of nitrogen nucleophiles are awarded. particular experimental techniques from the literature are supplied for the most important sessions of copper-catalyzed C?N coupling reactions. A tabular survey of all examples of Cu-catalyzed arylation and alkenylation of nitrogen nucleophiles is gifted in 35 tables equipped through nitrogen nucleophile and electrophilic coupling partner.

The literature is roofed via December 2015 and gives three hundred fresh citations to complement the 680 citations of the unique hardbound bankruptcy. those newest literature references were amassed in separate sections in accordance with the series of the tables within the tabular survey part. In all of the sections, the person citations were prepared in alphabetic order of the writer names.
Copper-Catalyzed Amination of Aryl and Alkenyl Electrophiles is meant to supply natural chemists with an available, yet special, creation to this significant type of transformations.

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