By Ken Ho (Ed.),Ken Ho

The molecular period ushered within the cloning of the expansion hormone (GH) gene and the construction of limitless quantities of GH via recombinant technology.  the continued momentum of analysis from simple technological know-how to medical evaluate has introduced unheard of advances to the certainty of GH biology for the scientific endocrinologist.   progress Hormone comparable ailments and treatment: A Molecular and Physiological viewpoint for the Clinician distills the entire new info of relevance to the endocrinologist during the last twenty years through delivering 5 sections: body structure, molecular genetics, GH deficiency, acromegaly and pharmacotherapy.   the 1st part on body structure specializes in GH action.

 

A evaluate at the constitution and serve as of the GH receptor is by way of a viewpoint at the regulatory position of ghrelin on GH secretion.  the second one part on genetics covers pituitary functionality and adenomas, together with new and interesting details on familial pituitary adenomas, their genotype and phenotype.  The grownup GH deficiency part spans the epidemiology and prognosis of GH deficiency with a robust reminder for the clinician that the transition interval represents a severe time of somatic maturation, which keeps for years after cessation of liner growth.  The part on acromegaly specializes in administration, giving useful courses to the worth of GH and IGF-1 measurements, where of somatostatin analogues and of radiotherapy whereas reminding the reader as to why comparing caliber of existence is a crucial a part of administration. ultimately, the part on GH pharmacology takes the reader via cutting edge advancements of long-acting GH formulations with a few items at the threshold of medical use.  This part offers a balanced facts established evaluate of the consequences of GH supplementation in getting older and in activities the place fresh info exhibits an bettering impact on a selective element of performance.  development Hormone comparable ailments and remedy: A Molecular and Physiological viewpoint for the Clinician integrates a wealth of knowledge and should end up a useful reference for pediatric endocrinologists, grownup endocrinologists, endocrine scientists and internists drawn to the human biology of GH.

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Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician (Contemporary Endocrinology) by Ken Ho (Ed.),Ken Ho


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